Search results for "TRH stimulation test"

showing 3 items of 3 documents

Hypothalamic-pituitary-thyroid axis in acromegaly

1983

To evaluate the hypothalamic-pituitary-thyroid axis in acromegaly, total and free thyroid hormones and TSH response to TRH were determined in 36 acromegalic patients. In 10 patients, rT3 and thyroxine binding globulin (TBG) were also assayed by radioimmunoassay. In 15 patients the TSH response to TRH was also studied after medical or surgical therapy of the acromegaly. In 34 patients total thyroid hormones were in the normal range whereas two patients had low serum levels of free thyroid hormones. Thirty-two of the acromegalic patients were euthyroid. However, only 43.7% of the euthyroid patients had a normal TSH response to TRH. Nine patients had a reduced TSH rise after TRH, whereas in 4 …

AdultMaleHypothalamo-Hypophyseal Systemendocrine systemmedicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismThyroid GlandThyrotropinThyroid Function TestsThyroxine-binding globulinEndocrinologyTRH stimulation testInternal medicineAcromegalymedicineHumansEuthyroidThyrotropin-Releasing Hormonebiologybusiness.industryThyroidMiddle Agedmedicine.diseaseHypothalamic–pituitary–thyroid axisThyroxinemedicine.anatomical_structureEndocrinologyHypothalamusAcromegalybiology.proteinTriiodothyronineFemaleThyroid functionbusinesshormones hormone substitutes and hormone antagonistsJournal of Endocrinological Investigation
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Hypogonadism in β-thalassemic adolescents: A characteristic pituitary-gonadal impairment. The ineffectiveness of long-term iron chelation therapy

1990

The pituitary-gonadal function was studied in 18 beta-thalassemic female adolescents, 8 with delayed puberty and 10 with primary amenorrhea,treated with repeated transfusions and long-term iron chelation therapy by subcutaneous infusion. A 100 micrograms gonadotropin-releasing hormone (GnRH) test, a double-bolus GnRH test after estradiol administration in non-responders, a 400 micrograms thyrotropin-releasing hormone (TRH) test and a 'high dose' human menopausal gonadotropin (hMG) test were performed. LH and FSH peak levels were significantly lower in thalassemic patients than in controls, both in the 100 micrograms GnRH test (LH was 4.3 +/- 0.7 mIU/ml vs 40.8 +/- 6.0 mIU/ml and FSH 3.3 +/-…

Delayed pubertyendocrine systemmedicine.medical_specialtyMenotropinsAdolescentendocrine system diseasesmedicine.drug_classIronEndocrinology Diabetes and MetabolismDeferoxamineGonadotropin-Releasing HormoneGnrh testEndocrinologyTRH stimulation testInternal medicinemedicineHumansChildThyrotropin-Releasing HormoneDose-Response Relationship DrugEstradiolbiologybusiness.industryHypogonadismOvaryObstetrics and GynecologyIron chelation therapyLuteinizing HormoneChelation TherapyProlactinProlactinEndocrinologyPituitary GlandHMG-CoA reductasebiology.proteinThalassemiaFemaleFollicle Stimulating Hormonemedicine.symptomGonadotropinbusinesshormones hormone substitutes and hormone antagonistsHormoneGynecological Endocrinology
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Pituitary resistance to thyroid hormone action with preserved circadian rhythm of thyrotropin in a postmenopausal woman.

1992

We assessed the 24-h behavior of circulating TSH and the dopaminergic control on TSH release in a postmenopausal woman, who had elevated levels of serum thyroid hormones and an inappropriately high concentration of serum TSH, indicating pituitary resistance to thyroid hormone action. The patient was found to have a daily profile of serum TSH similar to that of normal subjects, except for the persistently elevated 24 h levels, suggesting that alterations in thyroid hormone negative feedback control did not affect substantially circadian TSH rhythm. The acute administration of a dopamine antagonist drug (metoclopramide) resulted in a markedly elevated peak of serum TSH, similar both in the mo…

endocrine systemmedicine.medical_specialtyThyroid Hormonesendocrine system diseasesEndocrinology Diabetes and MetabolismDrug ResistanceThyrotropinThyroid Function TestsThyroid function testsHyperthyroidismEndocrinologyTRH stimulation testInternal medicinemedicineHumansCircadian rhythmmedicine.diagnostic_testbusiness.industryThyroidDopaminergicDopamine antagonistMiddle AgedBromocriptineCircadian Rhythmmedicine.anatomical_structureEndocrinologyPituitary GlandFemaleMenopausebusinesshormones hormone substitutes and hormone antagonistsHormonemedicine.drugJournal of endocrinological investigation
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